DONATO, NICHOLAS J.,FABBRO, DORIANO,MANLEY, PAUL WILLIAM,MESTAN, JUERGEN,WARMUTH, MARKUS,HALLEK, MICHAEL,TALPAZ, MOSHE,WU, JI
申请号：
CA2450777
公开号：
CA2450777C
申请日:
2002.08.09
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to a combination which comprises (a) at least onecompound decreasing the c-Src activity and (b) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamdio]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine or themonomethanesulfonate salt thereof to pharmaceutical compositions comprisingsaid combinations and to a method of treating a warm-blooded animal havingleukaemia, especially chronic myelogenous leukaemia, comprising administeringto the animal at least one compound inhibiting the activity of a member of theSrc kinase family,the Tec kinase family or a Raf kinase inhibitor, inparticular inhibiting the c-Src protein tyrosine kinase activity or inhibitingsimultaneously the c-Src protein tyrosine kinase activity and the Bcr-Abltyrosine kinase activity, alone or in combination with a Bcr-Abl inhibitor, inparticular N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine.
