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Use of c-Src inhibitors in combination with a pyrimidylaminobenzamide compound for the treatment of leukemia
专利权人:
Novartis AG
发明人:
Manley, Paul W.
申请号:
AU2012203659
公开号:
AU2012203659A1
申请日:
2012.06.22
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
#$%^&*AU2012203659A120120712.pdf#####Abstract The invention relates to a combination which comprises (a) at least one compound decreasing the c-Src activity and (b) a pyrimidylaminobenzamide compound to 5 pharmaceutical compositions comprising said combinations and to a method of treating a warm-blooded animal having leukemia, especially chronic myelogenous leukemia, comprising administering to the animal at least one compound inhibiting the activity of a member of the Src kinase family, the Btk kinase family, the Tec kinase family or a Raf kinase inhibitor, in particular inhibiting the c-Src protein tyrosine kinase activity or inhibiting 10 simultaneously the c-Src protein tyrosine kinase activity and the Bcr-Abl tyrosine kinase activity, in combination with a pyrimidylaminobenzamide compound, in particular 4-Methyl3-[[4-(3-pyridinyl)-2-pyrimidinyllamino]-N-[5-(4-methyl-1 H-imidazol-1 -yl)-3(trifluoromethyl)phenyl] benzamide.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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