A system and method for alerting an on-duty operator of the need to transfer operational control to an off-duty operator includes processing first and second physiological and activity data from the on-duty operator and the off-duty operator, respectively. The processor compares the fatigue state of the on-duty operator to a predetermined fatigue state threshold, and the rest state of the off-duty operator to a predetermined rest state threshold. The processor will generate an alert signal indicating that the on-duty operator should transfer operational control to the off-duty operator when (i) the fatigue state of the on-duty operator exceeds the predetermined fatigue state threshold or (ii) the rest state of the off-duty operator exceeds the predetermined rest state threshold.