THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;THE UNITED STATES GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERNS AFFAIRS
发明人:
PISEGNA, JOSEPH R.,GERMANO, PATRIZIA M.,VU, JOHN P.
申请号：
CA3049212
公开号：
CA3049212A1
申请日:
2018.01.04
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
In certain embodiments novel PAC1 receptor agonists are provided wherein the agonists comprise a targeting sequence that binds to the PAC1 receptor and said targeting sequence is attached to an amino acid sequence comprising a fragment of the maxadilan amino acid sequence, wherein the targeting sequence comprises a full-length 38 amino acid PACAP peptide or an N-terminus fragment thereof containing the amino acid sequence HSDGIF, wherein said targeting sequence optionally comprises an amino acid insertion between residues 11 and 12 of said PACAP peptide or fragment thereof； and the fragment of the maxadilan amino acid sequence comprises a fragment of the maxadilan sequence effective to activate PAC1 signaling.
