These substances are described as isoquinol compounds and their use as HPK1 inhibitors (blood oxyquinase type 1). These compounds help to treat HPK1-dependent disorders and enhance immune response. It also describes the inhibitory effect of HPK1, the therapeutic use of HPK1-dependent disorders and the use of enhancing immune response. Claim 1: A formula compound (1),As one of the acceptable salts for its drugs, R1 is hydrogen, halogen, cyanide and alkyl C8321833136.Cyoquilo C83238C83318327；Halogenated tar C832183531832626,Calcium hydroxide C83217C8331832626；Hydroxilo, alcoxilo C8321C 833126；Substituted amines or substituted hydrazines； R2 is (a),(b)(c)(d)(e)(f)(g) O (h): (a) A pagan with 5-10 members or 5-10 members, choosing 1-4 heteroatoms from O, S and N, can be replaced by 1, 2, 3, 4 or 5 substitutes； or (b) a C832683318321； 8320 can be replaced by 1, 2, 3, 4； Or five alternatives； or (c) hydrogen-NHSO8322； R74919；- SO8322； 7491； R74955；O-SO83228NH83222；A. Each R74919 is a separate C83218331832626 and R74955 is hydrogen or C83218331832626；O (d) - Or7491； 1 O - (lessor C83218331832626) - Or7491； 1；A. Each R7491, 1 independent C832131 degree-8326 selectively uses Arilo C83268331838321 and 8320；Isomerization of a.5-10 members； or isomerization of 5-10 members； isomerization of 5-10 members and 5-10 members； or (e) an alternative asphalt of C832183318326, replaced by a 1-5 substitute； or (f) a C832383318328OP； (g) - (c) (o) NR7491； - R749552；...2. Each r749192 is an independent hydrogen or C83218331832626 and R74955； 2 is hydrogen, namely C83218331832626；Isomerization isomerization of 5-10 members or 5-10 members, isomerization isomerization of 5-10 members, isomerization isomerization isomerization of 5-10 members, isomerization isomerization isomerization isomerization of 5-10 members can be substituted； or (h) isomerization isomerization isomerization isomerization of 5-10 members, merging with selected rings of 5 or 10 abiotic groups. Six members, 5-10 members,
