Yuqiang Wang,Lipeng Xu,Pei Yu,Yewei Sun,Zaijun Zhang,Gaoxiao Zhang,Peng Yi
申请号：
US15732636
公开号：
US20180147181A1
申请日:
2016.07.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides uses of an andrographolide derivative in preparation of a medicament for preventing and treating inflammatory bowel disease. The andrographolide derivative AL-1 has the mechanisms, for the treatment of ulcerative colitis, of scavenging of free radicals, inhibition of NF-κB signaling pathway activation and COX-2 expression, activation of PPAR-γ expression, and thus can prevent the transcription and expression of inflammatory-related genes to improve the conditions of inflammation. AL-1 can be used as a medicine for the treatment of inflammatory bowel disease and can be formulated to various dosage forms with a pharmaceutically acceptable carrier.
