An objective of the invention is to provide anti-C5 antibodies and methods of using the same. The invention provides anti-C5 antibodies and methods of using the same. In some embodiments, an isolated anti-C5 antibody of the present invention binds to an epitope within the β chain of C5 with a higher affinity at neutral pH than at acidic pH. The invention also provides isolated nucleic acids encoding an anti-C5 antibody of the present invention. The invention also provides host cells comprising a nucleic acid of the present invention. The invention also provides a method of producing an antibody comprising culturing a host cell of the present invention so that the antibody is produced. The invention further provides a method of producing an anti-C5 antibody comprising immunizing an animal against a polypeptide which comprises the MG1-MG2 domain of the β chain of C5. Anti-C5 antibodies of the present invention may be for use as a medicament.本發明的目的為提供抗C5抗體及其使用方法。本發明提供抗C5抗體及其使用方法。在一些實施例中，本發明的分離的抗C5抗體在中性pH比在酸性pH下以較高親和性結合至C5的β鏈內的抗原決定基。本發明亦提供編碼本發明的抗C5抗體的分離的核酸。本發明亦提供包括本發明的核酸的宿主細胞。本發明亦提供製造抗體的方法，包括培養本發明的宿主細胞以便製造抗體。本發明更提供製造抗C5抗體的方法，包括使動物對多肽免疫，所述多肽包括C5的β鏈的MG1-MG2域。本發明的抗C5抗體可作為藥物使用。
