A skin adhesive device is described that can be used in conjunction with a variety of medical devices that are held against a skin surface and/or that puncture the skin during a medical procedure. The device can be adhered to the skin and can hold the skin taut during a procedure so as to maintain the skin against a medical device and/or to prevent compression of subdermal structures during a procedure. Following use, the device can be simply removed from the skin surface and discarded.