The present invention provides a preparation method of carbonated apatite(CAp) by urea as additive, the method uses a urea as additive, and through heating, titration precipitation to get a carbonated Ca10(PO4)6(OH)2, so as to solve the Biocompatibity problems of HAp preparated by conventional way of using ammonia as additive.本發明係提供一種以尿素作為沉澱劑製備含碳酸根之氫氧基磷灰石的方法,該方法係利用一尿素作為沉澱劑,並經過加熱、滴定沉澱之步驟,以得到一含碳酸根之氫氧基磷灰石(carbonated Ca10(PO4)6(OH)2,簡稱CAp),藉以有效解決化學共沉澱法中,習用以氨水作為沉澱劑所製備之氫氧基磷灰石(Hydroxyapatite,HAp)具有生物相容性(Biocompatibity)之問題。