#$%^&*AU2016202344B220171130.pdf#####Abstract One aspect of the present invention relates to a double stranded nucleic acid useful as an siRNA, that has a sense 5 strand and an antisense strand relative to a target nucleic acid, where the sense strand contains one or more modified nucleobases, or one or more mismatch base pairings with the antisense strand. Another aspect of the present invention relates to a single-stranded 10 oligonucleotide comprising at least one nucleoside comprising a non-natural nucleobase. Another aspect of the invention relates to a method of gene silencing, comprising administering to a mammal in need thereof a therapeutically effective amount of a double-stranded 15 oligonucleotides containing a sense strand and an antisense strand, where the sense strand contains one or more modified nucleobases, or one or more mismatch base pairings with the anitsense strand. C: NRPortbl GHMatters MICHELES 7630500_1.docx 13/04/16
