Veera Konda,Jan Urban,Anuradha Desai,Clinton J. Dahlberg,Brian J. Carroll
申请号:
US14593164
公开号:
US09828331B2
申请日:
2015.01.09
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present application provides novel tetrahydro-isohumulone (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, inhibit inflammation, and treat conditions associated with inflammation and conditions responsive to PPARγ modulation such as diabetes.