KIENZLE, NORBERT ALEXANDER,CLARKE, ADAM WILLIAM,DOYLE, ANTHONY GERARD,JENNINGS, PHILIP ANTHONY,POLLARD, MATTHEW
申请号：
NZ59466810
公开号：
NZ594668A
申请日:
2010.03.16
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a VH binding domain, the binding domain comprising a first framework region, a first CDR1 (SGYSWH), a second framework region, a second CDR2 (HIHX8SGRPTYX9PSLX10S), a third framework region, a third CDR3 (KGKGSDDGLNY) and a fourth framework region. Alternatively disclosed is a VL binding domain, the binding domain comprising a first framework region, a first CDR1 (SASSSLSYIH), a second framework region, a second CDR2 (DTSNLAS), a third framework region, a third CDR3 (FQGSEYPLT) and a fourth framework region. Further disclosed is an antibody comprising two light chains and two heavy chains in which the sequence of the light chains is as shown in SEQ ID NO: 7 and the sequence of the heavy chains is as shown in SEQ ID NO: 94.
