GOVERNMENT OF THE UNITED STATES OF AMERICA; REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
MORGAN, RICHARD A.,ROSENBERG, STEVEN A.,HSU, CARY
申请号：
CA2590401
公开号：
CA2590401C
申请日:
2005.10.07
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention provides for compositions, e.g., pharmaceutical compositions,comprising a T lymphocyte, or a population thereof, expressing at least onerecombinant polynucleotide encoding a cytokine that enhances T lymphocytesurvival during the contraction phase of an immune response. The inventionfurther provides an isolated T lymphocyte, or population thereof, expressingat least one recombinant polynucleotide encoding the cytokine, wherein thepolynucleotide comprises a non-native coding sequence encoding the cytokine.Also provided is the use of such compositions and T lymphocytes, orpopulations thereof, for the treatment or prevention of a medical conditione.g., cancer. A method of preparing the a T lymphocyte with enhanced T cellsurvival is further provided herein.
