6-1--1--4--2-3-5-2--4----2---2--3- NOVEL POLYMORPHIC FORMS OF 6-1-METHYL-1H-PYRAZOL-4-YL-2-3-5-2-MORPHOLIN-4-YL-ETHOXY-PYRIMIDIN-2-YL-BENZYL-2H-PYRIDAZIN-3-ONE DIHYDROGENPHOSPHATE AND PROCESSES OF MANUFACTURING THEREOF
The present invention relates to a process for the preparation of 6- (1-methyl-1H-pyrazol-4-yl) -2- {3- [5- (2-morpholin- Benzyl} -2H-pyridazin-3-one dihydrogenphosphate, a solvate thereof and a crystalline modification product thereof. The present invention also relates to methods of producing such crystalline modifications, as well as to physiological and / or biochemical reactions which are induced, mediated and / or propagated by inhibition, regulation and / or modulation of signal transduction of kinases, in particular by tyrosine kinases To the use thereof in the treatment and / or prevention of pathological physiological diseases, for example pathological physiological diseases such as cancer.본 발명은 6-(1-메틸-1H-피라졸-4-일)-2-{3-[5-(2-모르폴린-4-일-에톡시)-피리미딘-2-일]-벤질}-2H-피리다진-3-온 디히드로겐포스페이트, 이의 용매화물 및 이의 결정질 개질체에 관한 것이다. 본 발명은 또한, 이러한 결정질 개질체의 제조 방법 뿐 아니라 키나아제의 신호 변환의 억제, 조절 및/또는 조정에 의해, 특히 티로신 키나아제의 억제에 의해 유발되고, 매개되고/되거나 증식되는 생리학적 및/또는 병리생리학적 병상, 예를 들어 암과 같은 병리생리학적 병상의 치료 및/또는 예방에서의 이의 용도에 관한 것이다.
