親油性化合物用の自己乳化性処方

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专利权人:

ベーリンガー・インゲルハイム・インテルナツィオナール・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング

发明人:

モロゾウィッチ,ウォルター,ガオ,ピン

申请号：

JP1999510972

公开号：

JP5005847B2

申请日:

1998.07.27

申请国别(地区):

JP

年份:

2012

代理人:

摘要：

The present invention provides a novel pharmaceutical composition based on the use of a particular oil phase which comprises a lipophilic, pharmaceutically active agent, a mixture of diglyceride and monoglyceride in a ratio of from about 9:1 to about 6:4 by weight (diglyceride:monoglyceride) wherein the diglyceride and monoglyceride are mono- or di- unsaturated fatty acid esters of glycerol having sixteen to twenty-two carbon chain length, one or more pharmaceutically acceptable solvents, and one or more pharmaceutically acceptable surfactants. The composition is in a form of self-emulsifying formulation which provides high concentration and high oral bioavailability for lipophilic compounds.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/