ALMA MATER STUDIORUM UNIVERSITA' DI BOLOGNA;ALMA MATER STUDIORUM UNIVERSITA DI BOLOGNA
发明人:
CAMPADELLI, MARIA GABRIELLA,GATTA, VALENTINA
申请号：
CA2974868
公开号：
CA2974868A1
申请日:
2016.02.11
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to the field of disease therapy. More specifically, it relates to a retargeted herpesvirus having a heterologous polypeptide fused to glycoprotein H, wherein the polypeptide targets diseased cells. It also relates to a nucleic acid comprising the genome of the herpesvirus of the invention, a vector comprising this nucleic acid and a cell comprising the nucleic acid or the vector. It further relates to killing cells using the herpesvirus of the invention and to methods for growing it in vitro.
