DERIVES DE CIS 3,4-DIHYDROXY-2-(3-METHYLBUTANOYL)-5-(3-METHYLBUTYL)-4-(4-METHYLPENTANOYL)CYCLOPENT-2-EN-1-ONE, COMPOSITIONS SUBSTANTIELLEMENT ENANTIOMERIQUEMENT PURES ET METHODES_
KINDEX THERAPEUTICS, LLC;CARROLL, BRIAN;DARLAND, GARY;DESAI, ANURADHA;KONDA, VEERA;DAHLBERG, CLINTON J.;URBAN, JAN
发明人:
CARROLL, BRIAN,DARLAND, GARY,DESAI, ANURADHA,KONDA, VEERA,DAHLBERG, CLINTON J.,URBAN, JAN
申请号：
CA2853974
公开号：
CA2853974A1
申请日:
2011.10.28
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present application provides cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3- methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives and substantially enantiomerically pure compositions thereof. These derivatives include (+)-(4S,5R)- 3,4- dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, (-)-(4R,5S)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4- methylpentanoyl)cyclopent-2-en-1-one, and salts and crystals thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPAR?, activate GPR120, inhibit inflammation, and treat conditions responsive to PPAR? modulation, conditions responsive to GPR120 modulation, and metabolic disturbances such as diabetes.
