PROBLEM TO BE SOLVED: To provide a lumen formation inhibitor which is characterized by not substantially inhibiting the growth of an endothelial cell with a deoxy sugar derivative or a sugar alcohol derivative as an effective component.SOLUTION: There is provided the lumen forming inhibitor which is characterized in that it does not substantially inhibit the growth of the endothelial cell with the deoxy sugar derivative or the sugar alcohol derivative except for 1, 5-Anhydro-2-deoxy-D-arabino-hexitol (ADAH, formula (4)) as the effective component. Particularly, D-Glucal (formula (1)) as the sugar alcohol derivative, or 2, 3-Dideoxy-D-erythro-hexose(DEH, formula (2)) as the deoxy sugar derivative, or Alkyl 2, 3-dideoxy-D-erythro-hexapyranoside (ADEH, formula (5)) is used as the effective component. (In the formula (5), R denotes a 1-5C alkyl group).COPYRIGHT: (C)2012,JPO&INPIT【課題】デオキシ糖誘導体、または糖アルコール誘導体を有効成分として、血管内皮細胞の増殖を実質的に阻害しないことを特徴とする管腔形成抑制剤を提供する。【解決手段】デオキシ糖誘導体、または1,5-Anhydro-2-deoxy-D-arabino-hexitol(ADAH、下式(4))を除く糖アルコール誘導体を有効成分として、血管内皮細胞の増殖を実質的に阻害しないことを特徴とする管腔形成抑制剤を提供する。特に、糖アルコール誘導体としてD-Glucal(下式(1))、もしくはデオキシ糖誘導体として2,3-Dideoxy-D-erythro-hexose(DEH、下式(2))、またはAlkyl 2,3-dideoxy-D-erythro-hexopyranoside(ADEH、下式(5))を有効成分とする。(式(5)で、Rは炭素数1~5のアルキル基を表す。)【選択図】なし
