A method of eliminating noise from an electrocardiography (ECG) signal and an ECG signal sensing apparatus thereof are provided. The method of eliminating noise from the ECG signal includes the following steps. The ECG signal is generated, and a median filtering process is performed on the ECG signal to obtain a median ECG signal. A calculation process is performed on the ECG signal and the median ECG signal, so as to obtain a detrended ECG signal.一種心電圖訊號的雜訊濾除方法以及其心電感測裝置。雜訊濾除方法包括下列步驟。產生心電圖訊號,並且對心電圖訊號進行中值濾波處理以取得中值心電圖訊號。對心電圖訊號以及中值心電圖訊號進行運算處理,藉以取得去趨勢心電圖訊號。S220、S240、S260‧‧‧心電圖訊號的雜訊濾除方法的步驟