The Brigham and Women's Hospital, Inc.;The General Hospital Corporation
发明人:
Paul B. Yu,Gregory D. Cuny,Kenneth D. Bloch,Randall T. Peterson,Charles C. Hong
申请号：
US13940641
公开号：
US09045484B2
申请日:
2013.07.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides pyridinyl-substituted pyrazolyl pyrimidine small molecule inhibitors of bone morphogenetic protein (BMP) signaling having the structure of formula (I),wherein variables A, B, E, F, X, Y, Z, Ar, L1, R4 and R15 are as defined in the specification. The compounds of the invention are useful in modulating cell growth, differentiation, proliferation, and apoptosis, and thus are useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.
