The present invention relates to a device for predicting an unfolded state of a foldable implant in biological tissue, the device comprising: a receiving unit configured to receive pre -treatment 3D planning image data and treatment image data, the treatment image data comprising catheter image data, the catheter image data comprising landmark image data； a segmentation module configured to segment the pre-treatment 3D planning image data resulting in segmented 3D planning image data； a search unit configured to locate the landmark image data within the treatment image data resulting in a known landmark position and a known landmark orientation； a registration module configured to register the segmented 3D planning image data to the treatment image data resulting in registered treatment image data； and a simulation unit configured to simulate an unfolded state of a foldable implant in biological tissue based on the known landmark position and the known landmark orientation in the biological tissue resulting in a simulated unfolded implant positioned in biological tissue. The present invention provides the knowledge of the unfolded implant in the biological tissue as well as its interaction with the anatomical placement domain at the current landmark position prior to the real deployment.
