Disubstituted benzothienyl-pyrrolotriazines and their use as fgfr kinase inhibitors

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专利权人:

BAYER INTELLECTUAL PROPERTY GMBH;BAYER PHARMA AKTIENGESELLSCHAFT

发明人:

BÖMER ULF,HÜBSCH WALTER,BROHM DIRK,HEROULT MELANIE,COLLIN MARIE-PIERRE,LUSTIG KLEMENS,GRÜNEWALD SYLVIA,VÖHRINGER VERENA,LOBELL MARIO

申请号：

NZ62507312

公开号：

NZ625073A

申请日:

2012.12.10

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Provided are disubstituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine compounds of the general formula (I), wherein the variables are as defined in the specification. Examples of the compounds include 4-{ [4-Amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl} piperazin-2-one and 4-{ [ 4-Amino-7-(ethoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methyl} piperazin-2-one. The compounds are FGFR kinase inhibitors. The compounds may be useful in the treatment of cancer.

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