Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compound. Examples of an orthomyxovirus viral infection include an influenza infection.本文揭示氮雜吡啶酮化合物、包括一或多種氮雜吡啶酮化合物之醫藥組合物,及其合成方法。本文亦揭示用氮雜吡啶酮化合物改善及/或治療包括正黏液病毒(orthomyxovirus)感染之疾病及/或病狀的方法。正黏液病毒之病毒感染之實例包括流感感染。