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Autotaxin inhibitors
专利权人:
CANCER RESEARCH TECHNOLOGY LIMITED
发明人:
Francesca Blum,James Lindsay Carr,Pritom Shah,Maria Del Mar Jimenez Quesada,Irene Farre Gutierrez
申请号:
US15547776
公开号:
US10138230B2
申请日:
2016.02.04
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention relates to compounds of formula (I): wherein R1, R2, R3, R4a, R4b, R4C, R4d, L, A, Q, W and HET are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated.
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