Paramjit S. ARORA,Ethel CESARMAN,Michael G. WUO,Jouliana SADEK
申请号:
US16684082
公开号:
US20200190155A1
申请日:
2019.11.14
申请国别(地区):
US
年份:
2020
代理人:
摘要:
This invention relates to macrostructures (and pharmaceutical formulations containing them) that include a parallel coiled-coil structure, wherein the parallel coiled-coil comprises a first coil of Formula I and a second coil of Formula II:T1-f0-g0-a1-b1-c1-d1-e1-f1-g1-a2-b2-c2-d2-e2-f2-g2-a3-b3-c3-d3-e3-T2 ; ;(I)T3-g′;0-a′;1-b′;1-c′;1-d′;1-e′;1-f′;1-g′;1-a′;2-b′;2-c′;2-d′;2-e′;2-f′;2-g′;2-a′;3-b′;3-c′;3-d′;3-e′;3-f′;3-T4 ; ;(II),as described in the present application. Methods of using these macrostructures are also disclosed.