GENENTECH, INC.;THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人:
BAELL, JONATHAN BAYLDON,LESSENE, GUILLAUME LAURENT,SLEEBS, BRAD EDMUND,FAIRBROTHER, WAYNE J.,FLYGARE, JOHN A.,KOEHLER, MICHAEL F. T.
申请号：
CA2666837
公开号：
CA2666837C
申请日:
2007.11.15
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention relates generally to small molecules that mimic the biological activity of certain peptides and proteins, to compositions containing them and to their use. In particular, the invention relates to compounds of the general formula (I) that mimic the biological activity of BH3-only proteins and are capable of binding to and neutralising prosurvival Bcl-2 proteins: wherein A1, A2, B1, B2, B3, X, Z, R1, R2, R3 and t are as described herein. The invention also relates to processes of preparing the benzenesulfonamide compounds that mimic portions of peptides and proteins, and to the use of such compounds in the regulation of cell death and the treatment and/or prophylaxis of diseases or conditions associated with the deregulation of cell death.
