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Benzopyran derivatives, method of production and use thereof
专利权人:
Université de Liège;Université Libre de Bruxelles
发明人:
SEBILLE, Sophie,PIROTTE, Bernard,BOVERIE, Stéphane,DE TULLIO, Pascal,LEBRUN, Philippe,ANTOINE, Marie-Hélène
申请号:
ES05707824
公开号:
ES2563455T3
申请日:
2005.01.21
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Benzopyran derivatives of the general formula ** Formula ** in which: D represents S or O; R1, R2, R3 and R4 are independently hydrogen, halogen, C1-6 alkyl, C3-8 cycloalkyl, hydroxy, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, nitro, amino, cyano, cyanomethyl, perhalomethyl, C 1-6 monoalkyl- or dialkylamino, sulfamoyl, C 1-6 alkylthio, C 1-6 alkylsulfonyl, C 1-6 alkylsulfinyl, formyl, C 1-6 alkylcarbonylamino, R8-arylthio, R8-arylsulfinyl, R8-arylsulfonyl, C 1-6 alkoxycarbonyl , C1-6-alkoxy-C1-6 alkyl, carbamoyl, carbamoylmethyl, monoalkyl- or C1-6 dialkylamino, monoalkyl- or C1-6-dialkylamino-thiocarbonyl, ureido, monoalkyl- or C1-6-carbonylamino, thioureido , mono- or C 1-6 dialkylamino-thiocarbonylamino, mono- or C 1-6 dialkylamino sulfonyl, carboxy, carboxy-C 1-6 alkyl, acyl, R 8 -aryl, R 8 -aryl-C 1-6 alkyl, R 8-aryloxy; R5 and R6 are each independently hydrogen, C1-6 alkyl or, R5 and R6 taken together with the carbon atom to which they are attached form a 3- to 6-membered carbocyclic ring; R7 is 2-, 3- or 4-pyridyl optionally mono- or polysubstituted with R1 or R7 is 2- or 3-thienyl optionally mono- or polysubstituted substituted with R1 or R7 is phenyl mono- or polysubstituted with R1 with the exception of R7 which represents C6H5; R 8 is hydrogen, halogen, C 1-6 alkyl, C 3-8 cycloalkyl, hydroxy, C 1-6 alkoxy, nitro, amino, cyano, cyanomethyl, perhalomethyl; or one of its salts with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, including a racemic mixture or any polymorphic and tautomeric form.Derivados de benzopirano de la fórmula general**Fórmula** en la que: D representa S u O; R1, R2, R3 y R4 son independientemente hidrógeno, halógeno, alquilo C1-6, cicloalquilo C3-8, hidroxi, alcoxi C1-6, alcoxi C1-6-alquilo C1-6, nitro, amino, ciano, cianometilo, perhalometilo, monoalquil- o dialquilamino C1-6, sulfamoílo, alquiltio C1-6, alquilsulfonilo C1-6, alquilsulfinilo C1-6, formilo, alquilcarbonilamino C1-6, R8-arilti
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