Douglas Carl Behenna,Hengmiao Cheng,Sujin Cho-Schultz,Theodore Otto Johnson, Jr.,John Charles Kath,Asako Nagata,Sajiv Krishnan Nair,Simon Paul Planken
申请号：
US14548749
公开号：
US09290496B2
申请日:
2014.11.20
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to compounds of formula (I)or pharmaceutically acceptable salts thereof, wherein Q, G, ring A, ring B, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, and m are defined herein. The novel purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
