Frank Bedu-Addo,Greg Conn,Siva K. Gandhapudi,Martin Ward,Jerold Woodward
申请号：
US16210750
公开号：
US20190321321A1
申请日:
2018.12.05
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods and compositions for modifying type I IFN signaling pathways in a subject comprising the administration a cationic lipid to the subject are provided. The cationic lipids comprise 1,2-dioleoyl-3-trimethylammonium propane (DOTAP), N-1-(2,3-dioleoyloxy)-propyl-N,N,N-trimethyl ammonium chloride (DOTMA), 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (DOEPC), enantiomers and combinations thereof. The compositions may further comprise one or more antigenic components, wherein such components are autologous or nonautologous.
