Methods and compositions comprising cationic lipids for stimulating type 1 interferon genes

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专利权人:

PDS Biotechnology Corporation

发明人:

BEDU-ADDO, Frank,CONN, Greg,GANDHAPUDI, Siva K.,WARD, Martin,WOODWARD, Jerold

申请号：

AU2018378588

公开号：

AU2018378588A1

申请日:

2018.12.05

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

Methods and compositions for modifying type I IFN signaling pathways in a subject comprising the administration a cationic lipid to the subject are provided. The cationic lipids comprise l,2-dioleoyl-3-trimethylammonium propane (DOTAP), N-l-(2,3-dioleoyloxy)-propyl- Ν, Ν, Ν-trimethyl ammonium chloride (DOTMA), l,2-dioleoyl-sn-glycero-3- ethylphosphocholine (DOEPC), enantiomers and combinations thereof. The compositions may further comprise one or more antigenic components, wherein such components are autologous or nonautologous.

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