David C. Litzinger;Lala Mamedova;Mary Erickson;Abhinandini Sharma;Zijian Guo;Soumitra S. Ghosh;Caroline Ekblad;Esther Odile Levy;Manoj P. Samant
发明人:
Mary Erickson,David C. Litzinger,Soumitra S. Ghosh,Zijian Guo,Manoj P. Samant,Abhinandini Sharma,Lala Mamedova,Esther Odile Levy,Caroline Ekblad
申请号：
US14129815
公开号：
US09382304B2
申请日:
2012.07.03
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including oral administration, and reduced immunogenicity. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including obesity and overweight, diabetes, dyslipidemia, hyperlipidemia, Alzheimer's disease, fatty liver disease, Short Bowel Syndrome, Parkinson's disease, and cardiovascular disease.
