THE BROAD INSTITUTE INC.;MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人:
Paul Blainey,Anthony Kulesa,Kan Xiong
申请号：
US15099371
公开号：
US20160243251A1
申请日:
2016.04.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to compositions which may comprise a non-naturally occurring or engineered artificial transcription factor, wherein the transcription factor may comprise a sequence specific DNA binding domain, a sliding domain, and one or more linkers, wherein the DNA binding domain and the sliding domain are operably connected by the one or more linkers, and uses thereof. Methods involving the use of a non-naturally occurring or engineered artificial transcription factors and pharmaceutical compositions, methods for treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.
