ZHU, WEI,ZHENG, QIANGANG,ZHANG, QINGWEI,ZHANG, LIN,TAO, RUIHONG,PATEL, MEENA V.,LUNDGAARD, GRETA L.,LI, MINGFENG,LEE, CHIH,HUNG - LANG, QINGYU,KONG, LINGLONG,HAZELWOOD, LISA A.,FU, LIQIANG,DENG, XIANG
申请号：
ARP170100880
公开号：
AR108185A1
申请日:
2017.04.05
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Amphetamine type stimulant compounds and salts that are medically acceptable can be used to treat conditions and disorders that can be prevented or improved by modulating the polyphosphate 1 receptor. 1. Characteristic requirement 1: a compound whose characteristic is formula (1) or a salt acceptable for a certain agent in the formula, wherein: select one compound from the formula group (2)；where RG¹ᵃ is selected from the group consisting of hydrogen and fluorine； RG¹ᵇ and RG¹ᵈ are independently selected from the group consisting of hydrogen, C₁₋₃alkoxy, and halogen； where C₁₋₃alkoxy is not substituted or is optionally substituted with one, two or three fluorine atoms； RG¹ᶜ is selected from the group consisting of hydrogen, C₁₋₃alkoxy, C₁₋₃alkyl, C₃₋₅cycloalkyl, halogen, and -NO₂；where the C₁₋₃alkyl and C₁₋₃alkoxy are not substituted or are optionally substituted with a hydroxyl or one, two or three fluorine atoms； where at least one of RG¹ᵇ,RGS758080,and RG¹ᵈ is not hydrogen； RG¹ᵉ and RG¹ᶠ are independently selected from the group consisting of hydrogen, C₁₋₃alkoxy, and -NHC (O) Rˣ；where the C₁₋₃alkoxy is not substituted or is optionally substituted with one, two or three fluorine atoms； Rˣ is C₁₋₃alkyl； where the C₁₋₃alkyl is not substituted or is optionally substituted with one, two or three fluorine atoms； RG¹ᵍ is selected from the group consisting of halogen and C₁₋₃alkoxy； where the C₁₋₃alkoxy is not substituted or is optionally substituted with one, two or three fluorine atoms； RG¹ʰ and RG¹ⁱ are independently selected from the group consisting of hydrogen, C₁₋₃alkoxy, and C₁₋₃alkyl；where C₁₋₃alkyl and C₁₋₃alkoxy are not substituted or are optionally substituted with one, two or three fluorine atoms； RG¹ʲ is selected from the group consisting of hydrogen or halogen； RG¹ᵏ and RG¹ˡ are independently selected from the group consisting of hydrogen and fluorine； RG¹ᵐ,RG070606,RG7510A,RG¹q, and RG¹ˢ are independently selected in each case from the group consisting o
