This also refers to pharmaceutical compositions comprising the compounds of formulas (1, 1a, 2A and 2B). Methods for preparing and using the compounds of formulas (1, 1a, 2A and 2B) are also within the scope of the present. Autoimmune diseases.Claim 1: a compound of the formula (1), where r\u00b9 is (a), phenyl optionally substituted with zero to four groups independently selected from the group consisting c\u2081\u208b\u2084 Halo, alkyl, alkoxy, and perhaloalquilo perhaloalcoxi or (b) heteroaryl, independently Select But the group that consists of the remains of the formulas (Group 3), where r\u1d4f selected,Regardless of the group consisting of H, alkyl, Halo, c\u2081\u208b\u2083, hydroxyl and alkoxy perhaloalquilo r\u02b2 selected, regardless of where c\u2081\u208b\u2083 H or alkyl, optionally substituted alkyl c\u2081\u208b\u2083 is one to three Halo Substituent or substituents, one Oh one Alkoxy Substituent and N is an integer of 0 - 3 X is n or cr\u00b2 R\u00b2 is H, alkyl or lower perhaloalquilo c\u2081\u208b\u2083 r\u00b3 is H,Perhaloalquilo, c\u2081\u208b\u2084 alcalcoxi, ch\u2082r\u2071, alkyl, - C (o) where the r\u1d49 or phenyl, phenyl optionally substituted with zero is two groups independently selected from the group consisting c\u2081\u208b\u2083 Halo, alkyl, alkoxy, and perhaloalquilo perhaloalcoxi r\u2071 is Oh, nc\u2083h\u2086, n (alkyl c\u2081\u208b\u2083) \u2082 or Halo r\u1d49 is Oh, c\u2081\u208b\u2083 or alkyl (alkyl, N \u2082, c\u2081\u208b\u2083)Or nc\u2083h\u2086 r\u2074 and r\u2075 are independently H or alkyl or phenyl piridilo c\u2081\u208b\u2083 r\u2078 is optionally substituted with zero to four substituents r\u1d50 where r\u1d50 is selected independently from the group consisting c\u2081\u208b\u2083 Halo alkyl, Hydroxy, alkoxy, and perhaloalquilo per Haloalcoxi or r\u2078 is selected independentlyThe Group consists of the remains of the group of formulas (4) and pharmaceutically acceptable salts of the compounds of formula (1).La pres
