KSANDER, GARY MICHAEL,MEREDITH, ERIK,MONOVICH, LAUREN G.,PAPILLON, JULIEN,FIROOZNIA, FARIBORZ,HU, QI-YING
申请号：
ES10175269
公开号：
ES2527209T3
申请日:
2006.08.23
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (III) ** Formula ** wherein R is hydrogen, (C1-C4) alkyl, (C2-C4) alkenyl, -C (O) O-R10, or --C (O) N ( R11) (R12), said (C1-5 C4) alkyl and (C2-C4) alkenyl are optionally substituted by one to three substituents independently selected from hydroxyl, (C1-C4) alkoxy, halo, -NH2, or (C1 -C4) - [(alkyl) (alkyl) N--]； wherein R10, R11 and R12 are independently hydrogen, (C1-C4) alkyl, (C6-C10) aryl- (C1-C4) alkyl--, (C3-C8) cylcoalkyl, or (C2-C4) alkenyl, each one of which is optionally substituted by one to three substituents independently selected from halo, hydroxyl, or (C1-C4) alkoxy； wherein R11 and R12 taken together with the nitrogen atom to which they are attached optionally form a 3-8 membered ring； R1, R2, R3, R4, and R5 are independently selected from hydrogen, halo, cyano, -NH2, (C1-C4) - [(alkyl) (alkyl) N- -], (C1-C4) alkoxy, (C2 -C4) alkenyl, (C1-C4) alkyl, (C1-C4) haloalkyl, (C6-C10) aryl, or heteroaryl of (5-9) -members, said (C1-C4) alkoxy, (C2-C4) alkenyl, (C1-C4) alkyl and (C6-C10) aryl being optionally substituted by one to three substituents independently selected from halo, (C1-C4) alkoxy, (C1-C4) alkyl, - -NH2, cyano, nitro, (C1-C4) alkoxy- (C1-C4) alkyl--, or (C1-C4) haloalkyl, with the proviso that no more than three of R1, R2, R3, R4, and R5 are simultaneously hydrogen； R and R1 taken together optionally form a 5-5 membered ring containing 0 or 1 heteroatoms selected from O, N or S； R6 and R7 are independently hydrogen, (C1-C4) alkyl, (C3-C8) cycloalkyl, (C1-C4) alkoxy, phenyl, or benzyl, said phenyl and benzyl are optionally substituted by one or three independently selected substituents halo, (C1-C4) alkyl, or (C1-C4) alkoxy； when R6 and R7 are linked to the same carbon atom, they optionally form a structural unit (A) represented by the following structure:, where Ra and Rb are independently hydrogen, or (C1-C4) alkyl, or Ra and Rb taken together with said carbon atom they optionally form a 3-8 member ring； or a compoun
