The present technology relates to methods and devices for the removal of toxins and pathogens from infected blood of patients. In particular, devices are designed to be portable, wearable, disposable and self-contained extracorporeal devices that can be easily assembled from a kitln one embodiment, the present invention provides a portable and/or wearable device for extracorporeal removal of a toxin and/or pathogen from blood of an individual infected with a toxin and/or pathogen.