GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED;ANACOR PHARMACEUTICALS, INC.
发明人:
ALEMPARTE-GALLARDO, CARLOS,阿列姆帕德 加拉多 卡洛斯,ALLEY, M. R. K. DICKON,艾里 Ｍ Ｒ Ｋ 狄肯,HERNANDEZ, VINCENT S.,赫南德兹 文森Ｓ,赫南德茲 文森Ｓ,PLATTNER, JACOB J.,普莱纳 雅各Ｊ,普萊納 雅各Ｊ,BARROS-AGUIRRE, DAVID,巴,阿列姆帕德 加拉多 卡洛斯,艾里 M R K 狄肯,赫南德兹 文森S,赫南德茲 文森S,普莱纳 雅各J,普萊納 雅各J
申请号：
TW105104376
公开号：
TW201643173A
申请日:
2016.02.15
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
Substituted benzoxaboroles whose structure comprises Formula Ill, wherein R3 is selected from -CH3, -CH2CH3, -CH2=CH2, -CH2CH2CH3, -CH(CH3)2, -CH2CH2=CH2, and cyclopropyl, R1 and R2 are each independently selected from H, -CH3, -CH2CH3, -CH2CH2CH3, and -CH(CH3)2； compositions containing such compounds, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.本發明提供經取代之苯并氧雜硼，其結構包含式III，其中R3係選自-CH3、-CH2CH3、-CH2=CH2、-CH2CH2CH3、-CH(CH3)2、-CH2CH2=CH2及環丙基，R1及R2各自獨立地選自H、-CH3、-CH2CH3、-CH2CH2CH3及-CH(CH3)2；含有此類化合物之組合物；其在療法中之用途，包括其作為抗分枝桿菌劑之用途，例如用於治療哺乳動物中之分枝桿菌感染；及用於製備此類化合物之方法。
