Present invention provides a compound of formula (I) [Formula 1] Wherein, Z 2 and Z 1 represents NH, Y is -C 3-9 alkyl -, - C 3-9 alkenyl -, - C 1-5 alkyl -NR 6 -C 1-5 alkyl -, - C 1-5 alkyl -NR 7 -CO-C 1-5 alkyl -, - C 1-6 alkyl -CO-NH -, - C 1-6 alkyl -NH-CO -, - C 1-2 alkyl -CO -Het 10 -CO -, - C 1-3 alkyl -NH-CO-Het 3 -, - Het 4 -C 1-3 alkyl -CO-NH-C 1-3 alkyl -, - C 1-2 alkyl - NH-CO-L 1 -NH -, - NH-CO-L 2 -NH -, - C 1-2 alkyl -CO-NH-L 3 -CO-, - C 1-2 alkyl -NH-CO-L 1-NH-CO-C 1-3 alkyl -, - C 1-2 alkyl -CO-NH-L 3 -CO-NH-C 1-3 alkyl -, - C 1-2 alkyl -NR 11 -CH 2 -CO-NH-C 1-3 alkyl -, Het 5 -CO-C 1-2 alkyl -, - C 1-5 alkyl -CO-NH-C 1-3 alkyl -CO-NH -, - C 1- -C 1-3 alkyl -CO-Het 28 -CO-NH- or 27 -CO- C 1-3 alkyl -NH-CO-Het- 5 alkyl -NR 13 -CO-C 1-3 alkyl -NH -, represents, X 1 is a direct bond, O, -O-C 1-2 alkyl -, - CO-C 1-2 alkyl -, - NR 16 -C 1-2 alkyl -, - CO-NR 17 -, Het 23 -C 1-2 alkyl - represents a C 1-2 alkyl or, X 2 is a direct bond, O, -O-C 1-2 alkyl -, - CO-C 1-2 alkyl -, - NR 18 -C 1-2 alkyl -, - CO-NR 19 -, Het 24 -C 1-2 alkyl - represents a C 1-2 alkyl or, R 5 and R 1 is hydrogen, halo, C 1-6 alkyl are each independently C 1-6 alkyloxy substituted with - - 1-4 alkyloxy or C Het 1 or - oxy represent, R 4 and R 2 represents hydrogen or halo are each independently, R 3 is hydrogen or cyano represents, R 19 and 13, R 17 R 6, R 7, R represents hydrogen, R 11 is represents hydrogen or C 1-4alkyl, R 18 R 16 and Het 17hydrogen, C 1-4 alkyl or represent, independently, L 3 and 1, L 2 L is phenyl, methylsulfide, cyano, C 1-4 alkyl polyhaloC optionally - 1-4 - alkyl-phenyl -C -, C 1-4 alkyloxy , pyridinyl, mono - a C may be substituted by two or more if possible or one is selected from C 3-6 cycloalkyl or - or di (C 1-4 alkyl) - amino- represents 1-8alkyl, 2, Het 17 Het 1, Het are each independently, represent a piperazinyl morpholinyl, oxazolyl, or isoxazolyl, morpholinyl, piperazinyl, 4, Het 5 Het 3, Het is piperidinyl or independently each represents pyrro
