Provided herein are methods of treating diseases, such as cancer, using a combination therapy. In certain embodiments, the methods comprise administering an effective amount of a phosphoinositide-3-kinase (PI3K) inhibitor and an effective amount of a cyclin-dependent kinase (CDK) inhibitor to a patient.本文提供使用組合療法治療諸如癌症之疾病的方法。在某些實施例中,該等方法包含向患者投與有效量之磷酸肌醇-3-激酶(PI3K)抑制劑及有效量之細胞週期素依賴型激酶(CDK)抑制劑。