The present invention is for use in the prevention and treatment of disorders and diseases related to the skin, the two specific categories compound, that is to provide novel compositions comprising a mixture of glass -B- ring flavonoids and Plastic half. The composition inhibits normal, the aging and damaged skin and in the tissue dehydratase cyclooxygenase (COX) and lipoxygenase dehydratase (LOX) enzymatic activity at the same time. The invention also provides a cyclooxygenase dehydratase (COX) and lipoxygenase methods for the prevention and treatment of skin disorders and diseases mediated by kinase (LOX). COX-2 and 5-LO-mediated skin diseases and ways to prevent and treat the disease is a single plant or multiple plants, especially Leah and Surgical Tella is synthesized from the genus Acacia plants and / or an isolated glass -B- ring flavonoids and a half Plata mixture and a pharmaceutically and / or cosmetically comprises a therapeutically effective amount of a composition comprising a carrier, which may be accepted by the local administration to the recipient in need thereof. Finally, the present invention Sunburn, laceration, acne, topical wounds, fungi, microbes and micro-inflammatory diseases which are caused by a virus infection, as bitil, systemic erythematosus, psoriasis, carcinoma, melanoma, and other mammal skin cancers, ultraviolet (UV) radiation, chemicals, heat, wind and dry skin damage caused by exposure to the environment, wrinkles, sagging skin, including, wrinkles and dark circles around the eyes, dermatitis and other allergy related skin diseases, but limited to, does not, the COX and LOX mediated diseases and disease prevention, and provides a method for the treatment. Use of the compositions described herein are also improved elasticity, reduced and delayed aging service, improved appearance and texture, and increased elastic young sex, robustness, the benefits of having a smooth and youthful skin smoothness and flexibility.본 발명은 피부에 관련된 질환 및