The invention relates to novel chroman derivatives, stereoisomers andpharmaceutically acceptable salts of Formula I, wherein the substituents areas defined in the specification. They are useful in the treatment of disordersmediated by lipoxygenase, such as immune diseases, respiratory diseases andcardiovascular diseases, as well as in the treatment of neurodegenerativedisorders and/or mitochondrial disorders. They are also useful in themanufacture of pharmaceutical formulations for the treatment of suchconditions.