Faure, Michel,Abrams, Tinya,Barsanti, Paul,Duhl, David,Renhowe, Paul A.,Walter, Annette Olga
申请号：
AU2008337570
公开号：
AU2008337570B2
申请日:
2008.12.12
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention provides novel imidazole compounds that inhibit the activity of kinesin spindle protein (KSP, also called Eg5). Inhibitors of KSP can reduce undesired cellular proliferation and provide other therapeutic effects. The invention also provides pharmaceutical compositions containing these novel compounds, and methods of using the novel KSP inhibitors and their pharmaceutical compositions to treat various types of cancers. The compounds, compositions and methods of the invention are especially useful for treating certain classes of cancers that are resistant to conventional drug treatments, because such cancers are shown to remain sensitive to the compounds of the invention.
