INSTITUTE OF NUCLEAR ENERGY RESEARCH; ATOMIC ENERGY COUNCIL
发明人:
CHENG, CHUN-CHIA,程俊嘉,程俊嘉,LUO, TSAI-YUEH,罗彩月,羅彩月
申请号：
TW103128519
公开号：
TW201607542A
申请日:
2014.08.19
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
Albumin and doxorubicin are processed through a bonding reaction to be purified with water in a column. The bonded albumin and doxorubicin are added with a nano-gold solution for reaction. After being purified, the solution phase is changed to a phosphate buffer for obtaining a nano-gold-doxorubicin anticancer drug. Thus, with the high biocompatibility and the high surface area, the nano-gold solution is used in biological applications as a carrier for increasing accumulation of drug on tumor. The bonding between nano-gold and doxorubicin increases stability of doxorubicin. Besides, doxorubicin has tumor-killing effect, so effective therapy for cancer can be achieved.一種奈米金與doxorubicin之鍵結方法,其包含以白蛋白與阿黴素(doxorubicin)進行鍵結反應,完成白蛋白鍵結doxorubicin,並於管柱中以純水純化後,加入奈米金溶液進行反應,且再純化後使其液相轉換為磷酸鹽緩衝液,取得奈米金-doxorubicin抗癌藥物。藉此,可利用奈米金溶液之高生物相容性及高表面積特性作為生物應用及增加藥物聚集腫瘤之載體,奈米金鍵結doxorubicin可增加doxorubicin之穩定性,並利用doxorubicin具有腫瘤毒殺效果,達到有效運用於治療癌症之功效。1‧‧‧步驟(A)白蛋白與DOX之鍵結與純化2‧‧‧步驟(B)奈米金與白蛋白-DOX之鍵結與純化
