Methods for the production of 3-O-deactivated-4′-monophosphoryl lipid A (3D-MLA)

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专利权人:

发明人:

Kent R. Myers,D. Scott Snyder

申请号：

US14271431

公开号：

US09512159B2

申请日:

2014.05.06

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The invention relates to a method for extracting lipopolysaccharide (LPS) from rough trough mutant bacteria cells by extracting the cells with an aqueous aliphatic alcohol having from 1 to 4 carbon atoms at a temperature between 35 and 65 degrees C. to produce cells having a reduced phospholipid content. The resultant cells are then extracted with chloroform/methanol to yield LPS.

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