可抑制ＭＥＫ之５-取代-２-苯胺-苯甲醯胺

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

ISSHIKI, YOSHIAKI,一色义明,一色義明,KOHCHI, YASUNORI,河内靖典,河內靖典,MIZUGUCHI, EISAKU,水口荣作,水口榮作,IIKURA, HITOSHI,饭仓仁,飯倉仁,MATSUBARA, YASUAKI,松原靖昭,TSUJII, SHINJI,辻井伸治,SHIMMA, NOBUO,新间信夫,新間信夫,MIWA, MASANORI

申请号：

TW094125122

公开号：

TWI361066B

申请日:

2005.07.25

申请国别(地区):

TW

年份:

2012

代理人:

摘要：

An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R 1 , R 2 , R 3 , R 4 , and X are the same as defined in the present patent application].本發明係提供具有強烈的MEK抑制活性、可穩定存在於活體內並可溶於水中之化合物，其可作為用於增生性病變之預防性或治療性之製劑。；本發明之化合物及其藥學上可接受之鹽類係由下列化學式(1)所代表：(其中，R1、R2、R3、R4以及X均與本專利申請案中所定義者相同)。

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中国工程科技知识中心

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