The present invention relates to a method for manufacturing a sustained release microsphere which is able to continuously control the release of a drug. More specifically, the present invention relates to a method for manufacturing a sustained release microsphere through a solvent flow evaporation method using a cosolvent when manufacturing a microsphere in which a drug is sealed in a carrier comprising biodegradable polymers. Thus, early excessive release of a physiologically active substance is suppressed so the physiologically active substance can be continuously and uniformly released in the body.La présente invention concerne un procédé de fabrication dune microsphère à libération lente pouvant réguler en continu la libération dun médicament. Elle concerne plus particulièrement un procédé de fabrication de microsphère à libération lente au moyen dune technique dévaporation dun flux de solvant utilisant un cosolvant lors de la fabrication dune microsphère dans laquelle un médicament est encapsulé dans un support contenant des polymères biodégradables. Cette technique empêche une libération excessive précoce dune substance physiologiquement active et assure une diffusion continue et uniforme de celle-ci dans le corps.본 발명은 지속적으로 약물의 방출을 조절할 수 있는 서방출성 미립구의 제조방법에 관한 것으로, 보다 상세하게는 생분해성 고분자로 이루어진 담체에 약물을 봉입한 미립구를 제조함에 있어 공용매를 사용한 용매교류증발법을 사용함으로써 생리활성물질의 초기 과다방출을 억제하여 체내에서 생리활성물질이 지속적이고 균일하게 방출될 수 있도록 한 서방출성 미립구의 제조방법에 관한 것이다.
