invention diabetes drug Januvia (Januvia) of the key intermediate of Formula 2 of compound a simple the method step to provide a method for producing a cost-effective and high-yield . [ Formula 2] Wherein , R is Boc [t- butyloxycarbonyl (t-butyloxycarbonyl)], Cbz [ benzyloxycarbonyl (benzyloxylcarbonyl)], Fmoc [ fluorene- carbonyl -methyl- butyloxycarbonyl (fluorenylmethyloxycarbonyl)], acetylation (acetyl) or the benzoyl (benzoyl).본 발명은 당뇨병 치료제인 자누비아(Januvia)의 핵심 중간체인 [화학식 2]의 화합물을 간단한 공정방법으로 경제적이고 높은 수율로 제조하는 방법을 제공한다. [화학식 2]상기 식에서, R은 Boc[t-부틸옥시카보닐(t-butyloxycarbonyl)], Cbz[벤질옥시카보닐(benzyloxylcarbonyl)], Fmoc[플루오렌닐메틸옥시카르보닐 (fluorenylmethyloxycarbonyl)], 아세틸(acetyl) 또는 벤조일(benzoyl) 이다.
