PROBLEM TO BE SOLVED: To provide a compound having a pyruvate dehydrogenase inhibitory activity and useful for preventing or treating diabetes, metabolic syndrome, hyperlacticacidemia, cardiac failure, cardiomyopathy, cardiac angina, lipid abnormality, atherosclerosis, peripheral arterial disorders, intermittent claudication, chronic obstructive pulmonary disease, cerebral stroke, mitochondrial disease, cancer, pulmonary hypertension, etc.； and a pharmaceutical composition including the compound.SOLUTION: The provided fluorene-amide compound is expressed by the following formula； an enantiomer of the same or medically permissible salt of the same and pharmaceutical compositions including these substances are also provided.【課題】ピルビン酸デヒドロゲナーゼキナーゼ阻害活性を有し、糖尿病、メタボリックシンドローム、高乳酸血症、心不全、心筋症、狭心症、脂質異常症、アテローム性硬化症、末梢動脈疾患、間欠性跛行、慢性閉塞性肺疾患、脳卒中、ミトコンドリア病、癌、肺高血圧症等の予防又は治療に有用な化合物、及び該化合物を含有する医薬組成物の提供。【解決手段】下式で示されるフルオレン－アミド化合物又はその光学異性体或いはその医学的に許容される塩、及びそれらを含有する医薬組成物。【選択図】なし
