Cannula and handle systems and cannulas having substantially continuous interior pathways or channels are provided. The interior pathway may extend from the inlet to the cannula to the outlet, such that tissue collected at the inlet is carried to the outlet without contacting other components. Moreover, the substantially continuous nature of the interior pathway, with an absence of drop-offs, blind pockets or other discontinuities, facilitates cleaning. In addition, inlet holes are sized to promote the transfer of tissue through the channel to the outlet, and to the avoidance of damaging collected tissue.
