CHOI, YOON HWAN,최윤환,SHIN, YOUNG GYUN,신영균,CHANG, WON TAE,장원태,CHOI, TAE GUN,최태근,PARK, SANG HOO,박상후
申请号：
KR1020110146178
公开号：
KR1020130077458A
申请日:
2011.12.29
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A manufacturing method of the benzodiazepine derivative is provided to offer a simple production process and economic benefits not by using the expensive catalyst, and to safely mass-produce the high-yield of benzodiazepine derivative as there is not in danger of ignition or explosion.CONSTITUTION: A manufacturing method of the benzodiazepine derivative comprises the step of manufacturing the compound which is represented by the chemical formula 1 by the reduction reaction between a reducing agent and the compound represented by chemical formula 2. The above manufacturing method of the benzodiazepine derivative is performed by reacting the compound represented by chemical formula 2 with the reducing agent at a mol ratio of 1:0.5-1:10. The above reduction reaction occurs at 0 through 100°C. The above compound represented by chemical formula 2 is manufactured by cyclizing the compound represented by chemical formula 3 under the presence of base basic condition. The base is the one of the group comprised of sodium hydroxide and potassium hydroxide.COPYRIGHT KIPO 2013본 발명은 벤조디아제핀 유도체의 새로운 제조방법에 관한 것으로, 화학식 2로 표시되는 화합물을 환원제로 환원 반응시켜 화학식1로 표시되는 화합물을 제조하는 단계를 포함하는 벤조디아제핀 유도체의 제조방법에 의하는 경우 생산공정이 기존의 제조방법보다 단순하고, 고가의 촉매를 사용하지 않아 경제적이며, 인화 및 폭발 위험이 없어 안전하게 벤조디아제핀 유도체를 높은 수율로 대량생산 할 수 있다.
